Treatment Strategy for Multiple Colorectal Liver Metastases

Introduction: There are several controversies in the treatment strategy for multiple CRLM. Methods: Two hundred and fifty-eight patients underwent initial hepatectomy CRLM from 2001 to 2018. Clinicopathological data long-term outcomes were retrospectively analyzed. Results: MST 5-year OS 46 months 41.6%, which significantly worse compared that with solitary (Group S) (125 69.2%, p<0.001). R1 resection was an independent poor prognostic factor Group S but not M. The rate of hepatic recurrence 58.8% M, high (39.5%, p=0.07). repeat relatively (p=0.09) no difference between major minor hepatectomy, whereas, after (63.6% vs 36.8%, p=0.009). absence factor. Pre- post-operative chemotherapy resectable cases associated improved survival. In subgroup analysis, postoperative a better prognosis synchronous Additionally, CRLM, comparable R0 when administrated appropriately. Conclusion: Although is prognosis, might be aggressive using parenchyma preserving hepatectomy. Systemic may contribute improving according tumor conditions.